MECHANISM OF ACTION:

The antimicrobial activity of the combination of trimethoprim and sulfamethoxazole resultsfrom its actions or two steps of the enzymatic pathway for the synthesis of tetrahydrofolic acid. Sulfonamide inhibits the incorporation of PABA into folic acid and trimethoprim prevents the reduction of dehydrofolate to tetrahydrofolate. The latter is the form of folate essential for one carbon trasfer reactions. The synergistic interaction between the sulfonamide and trimethoprim is this predictable from their respective mechanism.

INDICATIONS:

Urinary tract infections, respiratory tract infections, gastro-intestinal tract infections, and other infections suspectible to its components.

FORMULATION:

Each 5 mL (1 teaspoonful) contains:
Sulfamethoxazole ……………………… 200 mg
Trimethoprim …………………………. 40 mg

DOSAGE:

Suspension:
6-12 years: 10 mL (2 teaspoonful)
2-6 years: 5 mL (1 teaspoonful)
Below 2 years: 2.5 mL (1/2 teaspoon). Twice a day or as prescribed by the physician.

PRECAUTION:

In cases with renal impairment, a reduced or more widely spaced dosage is indicated to avoid accumulation in the blood. For such patient measurement of plasma concentration are advisable. Regular blood count are recommended whenever Cotrimoxazole is given to a long period. Nausea, vomiting, glossitis and skin rashes have occasionally been reported and high doses may cause diarrhea in small number of patients treated with Cotrimoxazole.

CAUTION:

Foods, Drugs, Devices and Cosmetics Act prohibits dispensing without prescription.

AVAILABILITY:

Strip Foil of 10′s; box of 100′s
Blister Pack of 10′s box of 20′s and 100′s
Bottle x 60 mL & 75 mL

STORAGE CONDITION:

Store at temperatures not exceeding 30 degree Celsius.

SHAKE WELL BEFORE USING.